Karel marquez is a daughter of Pinky Marquez, who is also an actress, model and singer and Dr. Eduardo Santos. She has also two siblings..
She has a role in a GMA primetime, Zaido, as Lyka. She has been one half of the covergirls in November 2006 edition of FHM Magazine, along with Amanda Griffin. Karel, along with Drew Arellano, is also a co-host in Coca Cola: Ride To Fame, a reality talent show after SOP Rules.